Al Pacino
Benjamin «Lefty» Ruggiero

Anne Heche
Maggie Pistone

Brian Tarantina
Bruno

Bruno Kirby
Nicky

Gerry Becker
Dean Blandford

James Russo
Paulie

Johnny Depp
Donnie Brasco, Joseph D. «Joe» Pistone

Larry Romano
Tommy Ruggiero

Michael Madsen
Sonny Black

Paul Giamatti
FBI Technician

Robert Miano
Sonny Red

Rocco Sisto
Richard «Richie» Gazzo

Ronnie Farer
Annette

Terry Serpico
Strip Club Owner

Tim Blake Nelson
FBI Technician

Zach Grenier
Dr. Berger

Zeljko Ivanek
Tim Curley