Bing Russell
Harry, barman à Griffin

Burt Lancaster
Marshal Wyatt Earp

DeForest Kelley
Morgan Earp

Dennis Hopper
Billy Clanton

Don Castle
Cowboy ivre au saloon de Longbranch

Earl Holliman
Deputy Sheriff Charles «Charlie» Bassett

Frank Faylen
Cotton Wilson, county sheriff, Griffin, Texas

George Mathews
John Shanssey, propriétaire du saloon de Griffin

Jack Elam
Tom McLowery

Jo Van Fleet
Kate Fisher

John Hudson
Virgil Earp

John Ireland
Johnny Ringo

Kirk Douglas
Dr. John «Doc» Holliday

Lee Van Cleef
Ed Bailey

Lyle Bettger
Ike Clanton

Martin Milner
James «Jimmy» Earp

Mickey Simpson
Frank McLowery

Olive Carey
Mrs. Clanton

Rondha Fleming
Laura Denbow

Ted de Corsia
Shanghai Pierce